Jason Alba, creator of JibberJobber, also the writer for the JibberJobber blog, has a good post on using Twitter effectively. I agree: people are busy, they don't like technology, and there isn't a great deal of evidence yet that all of the effort put into job seeking on Twitter can actually lead to a job.
For librarians, using Twitter for information sharing makes sense. If you just happen to get a job out of it, double bonus points.